Chemical reversal of abnormalities in cells carrying mitochondrial DNA mutations

November 9th, 2020 by Hiroki Kobayashi

Nature Chemical Biology, Published online: 09 November 2020; doi:10.1038/s41589-020-00676-4

Tryptolinamide (TLAM) is a small molecule compound that inhibits phosphofructokinase-1 activity and rescues the metabolic defects of patient-derived induced pluripotent stem cell lines with mutated mitochondrial DNA.
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