Chemical reversal of abnormalities in cells carrying mitochondrial DNA mutations
November 9th, 2020 by Hiroki Kobayashi
Nature Chemical Biology, Published online: 09 November 2020; doi:10.1038/s41589-020-00676-4
Tryptolinamide (TLAM) is a small molecule compound that inhibits phosphofructokinase-1 activity and rescues the metabolic defects of patient-derived induced pluripotent stem cell lines with mutated mitochondrial DNA.