Extracellular phosphorylation drives the formation of neuronal circuitry

August 26th, 2019 by Hidekiyo Harada

Nature Chemical Biology, Published online: 26 August 2019; doi:10.1038/s41589-019-0345-z

Via its receptor LRP5, Wnt3a stimulates axonal growth in retinal ganglion neurons. Phosphorylation of co-receptor RGMb by VLK induces LRP5 internalization to limit Wnt3a signaling and reduce axon growth.
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