Global targeting of functional tyrosines using sulfur-triazole exchange chemistry

November 25th, 2019 by Heung Sik Hahm

Nature Chemical Biology, Published online: 25 November 2019; doi:10.1038/s41589-019-0404-5

Sulfur-triazole exchange (SuTEx) chemistry is a tunable platform for covalent chemoproteomic probes that selectively target tyrosines, used to identify residues with enhanced nucleophilicity and monitor activation of phosphotyrosine sites.
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