Rendezvous of Retro-2 at the ER

February 17th, 2020 by Hesso Farhan

Nature Chemical Biology, Published online: 17 February 2020; doi:10.1038/s41589-020-0475-3

Retro-2 is a drug that protects cells against bacterial and plant toxins by arresting their trafficking in endosomes. New data show that the target for Retro-2 is surprisingly not within the endosomal system, but on the endoplasmic reticulum.