Metabolic engineering of a carbapenem antibiotic synthesis pathway in <i>Escherichia coli</i>

June 25th, 2018 by Helena Shomar

Metabolic engineering of a carbapenem antibiotic synthesis pathway in Escherichia coli

Metabolic engineering of a carbapenem antibiotic synthesis pathway in <i>Escherichia coli</i>, Published online: 25 June 2018; doi:10.1038/s41589-018-0084-6

Efficient production of a simple carbapenem antibiotic in Escherichia coli is achieved by a combination of feedback-resistant enzymes for increased precursor biosynthesis and inhibition of fatty acid synthesis for tolerance toward the toxic product.
  • Posted in Nat Chem Biol, Publications
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