A nucleotide-switch mechanism mediates opposing catalytic activities of Rel enzymes
May 11th, 2020 by Hedvig Tamman
Nature Chemical Biology, Published online: 11 May 2020; doi:10.1038/s41589-020-0520-2
Structural and smFRET analysis reveals the mechanism of opposing catalytic activities of bifunctional Rel enzymes; that is, activation of one of the catalytic domains leads to allosteric inactivation of the other.