A nucleotide-switch mechanism mediates opposing catalytic activities of Rel enzymes

May 11th, 2020 by Hedvig Tamman

Nature Chemical Biology, Published online: 11 May 2020; doi:10.1038/s41589-020-0520-2

Structural and smFRET analysis reveals the mechanism of opposing catalytic activities of bifunctional Rel enzymes; that is, activation of one of the catalytic domains leads to allosteric inactivation of the other.
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