Breaking up is hard to do

August 26th, 2019 by Heather A. Van Epps

Nature Chemical Biology, Published online: 26 August 2019; doi:10.1038/s41589-019-0351-1

A comprehensive genetic screen reveals new cellular trafficking factors and linker-dependent requirements for antibody–drug conjugate (ADC) cytotoxicity. These new insights may guide the design of optimized ADCs.