Redox regulation: Scaffolding H2O2 signaling
July 18th, 2017 by Hadley D Sikes
Nature Chemical Biology 13, 818 (2017). doi:10.1038/nchembio.2432
Author: Hadley D Sikes
Peroxidases, rather than simply reducing H2O2 to water, also convey oxidation signals to proteins such as transcription factors. A new study reveals how a scaffold protein enables formation of a mixed disulfide between the peroxidase and a transcription factor.