LYTACs that engage the asialoglycoprotein receptor for targeted protein degradation

March 25th, 2021 by Green Ahn

Nature Chemical Biology, Published online: 25 March 2021; doi:10.1038/s41589-021-00770-1

Lysosome-targeting chimeras (LYTACs) based on glycan ligands of the asialoglycoprotein receptor facilitate the cell-specific targeting and turnover of proteins by lysosomal enzymes, expanding the scope of LYTAC-mediated targeted protein degradation.
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