Functional characterization of a PROTAC directed against BRAF mutant V600E

August 10th, 2020 by Ganna Posternak

Nature Chemical Biology, Published online: 10 August 2020; doi:10.1038/s41589-020-0609-7

A PROTAC termed P4B targeting BRAF V600E mutant has been developed, which displays enhanced inhibitory function in cell lines carrying BRAF mutations that impart resistance to conventional BRAF inhibitors.
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