A class of highly selective inhibitors bind to an active state of PI3Kγ

February 4th, 2019 by Gangadhara Gangadhara

A class of highly selective inhibitors bind to an active state of PI3Kγ

A class of highly selective inhibitors bind to an active state of PI3Kγ, Published online: 04 February 2019; doi:10.1038/s41589-018-0215-0

Combining X-ray structures, surface plasmon resonance and hydrogen-deuterium exchange–mass spectrometry, a class of highly selective inhibitors was found to bind to an active state of PI3Kγ breaking a conformational ‘lock’ important for activation of PI3Kγ.
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