In vivo chloride concentrations surge to proteotoxic levels during acid stress

October 15th, 2018 by Frederick Stull

In vivo chloride concentrations surge to proteotoxic levels during acid stress

In vivo chloride concentrations surge to proteotoxic levels during acid stress, Published online: 15 October 2018; doi:10.1038/s41589-018-0143-z

Protonation of periplasmic protein carboxylic groups creates a Donnan equilibrium in the bacterial periplasmic space at low pH, leading to accumulation of Cl− and unfolding and aggregation of periplasmic proteins, which can be rescued by chaperones.
  • Posted in Nat Chem Biol, Publications
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Folding against the wind

March 5th, 2018 by Frederick Stull

Folding against the wind

Folding against the wind, Published online: 05 March 2018; doi:10.1038/s41589-018-0016-5

Many thermodynamically unfavorable processes in biology are powered by ATP, the energy currency of the cell. New evidence suggests that chaperone-mediated protein stabilization may need to be added to that list.