Membrane enzymes: Transformers at the interface

January 12th, 2015 by Florian Brodhun

Nature Chemical Biology 11, 102 (2015). doi:10.1038/nchembio.1738

Authors: Florian Brodhun & Kai Tittmann

Recent studies on two enzyme classes operating at the membrane interface showcase an unanticipated degree of structural plasticity involving domain swapping and marked secondary structure reshuffling. This structural variability in topology is key to functional diversification and catalytic prowess.