Probe discovery: Disentangling gene networks

December 17th, 2015 by Finbarr Hayes

Nature Chemical Biology 12, 3 (2016). doi:10.1038/nchembio.1983

Author: Finbarr Hayes

Cell-wall biogenesis in bacteria involves multiple intersecting gene networks. A powerful approach that allies synthetic lethality with small-molecule discovery has now been used to probe these networks and has revealed that the pathway for D-alanylation of teichoic acids in Staphylococcus aureus is a viable target for new antibacterials.