Structural basis for antibiotic action of the B<sub>1</sub> antivitamin 2′-methoxy-thiamine

August 24th, 2020 by Fabian Rabe von Pappenheim

Nature Chemical Biology, Published online: 24 August 2020; doi:10.1038/s41589-020-0628-4

Structural and biochemical analysis of E. coli transketolase with 2′-methoxy-thiamine shows that this antivitamin selectively inhibits the bacterial enzyme via a steric clash with a critical glutamate residue, preventing cofactor activation.
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