Structural and mechanistic basis of mammalian Nudt12 RNA deNADding

May 17th, 2019 by Ewa Grudzien-Nogalska

Nature Chemical Biology, Published online: 17 May 2019; doi:10.1038/s41589-019-0293-7

Structural and biochemical analyses identify Nudt12 as a novel mRNA deNADing enzyme in mammalian cells, which has a different substrate preference compared to the deNADing enzyme DXO.