Discovery of a ZIP7 inhibitor from a Notch pathway screen

January 14th, 2019 by Erin Nolin

Discovery of a ZIP7 inhibitor from a Notch pathway screen

Discovery of a ZIP7 inhibitor from a Notch pathway screen, Published online: 14 January 2019; doi:10.1038/s41589-018-0200-7

A cell-based phenotypic screen identifying inhibitors of Notch signaling led to the discovery of NVS-ZP7-4, which blocks the activity of the zinc transporter SLC39a7 (ZIP7) and induces cell death through an ER stress mechanism.