TRP Channels: Pain enters through the side door

February 14th, 2014 by Emily R Liman

Nature Chemical Biology 10, 171 (2014). doi:10.1038/nchembio.1470

Author: Emily R Liman

TRPM3 can permeate ions through two distinct pores—the central pore and a likely alternative 'omega pore'. Entry of ions through the alternative pore of TRPM3 contributes to pain generation, making it an attractive target for the design of new analgesics.