New codons for efficient production of unnatural proteins in a semisynthetic organism

April 6th, 2020 by Emil C. Fischer

Nature Chemical Biology, Published online: 06 April 2020; doi:10.1038/s41589-020-0507-z

Systematic characterization of codons using the unnatural base pair dNaM·dTPT3 leads to the discovery of nine new functional codon–anticodon pairs, three of which are shown to be orthogonally decoded by ribosomes and allow incorporation of up to three noncanonical amino acids in Escherichia coli.
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