Discovery of a NAPE-PLD inhibitor that modulates emotional behavior in mice

May 11th, 2020 by Elliot D. Mock

Nature Chemical Biology, Published online: 11 May 2020; doi:10.1038/s41589-020-0528-7

An inhibitor of NAPE-PLD involved in lipid biosynthesis lowers levels of the endocannabinoid anandamide and other N-acylethanolamines in cells and mouse brain and activates the hypothalamus–pituitary–adrenal axis and impaired fear extinction.
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