Fosmidomycin biosynthesis diverges from related phosphonate natural products

August 26th, 2019 by Elizabeth I. Parkinson

Nature Chemical Biology, Published online: 26 August 2019; doi:10.1038/s41589-019-0343-1

The biosynthetic pathway for the phosphonate natural product dehydrofosmidomycin differs from that of the related compound FR-900098, involving rearrangement of a two-carbon phosphonate precursor catalyzed by a 2-oxoglutarate-dependent dioxygenase.
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