An optical sensor to monitor dynamics of extracellular glycine

August 17th, 2018 by Dmitri A. Rusakov

An optical sensor to monitor dynamics of extracellular glycine

An optical sensor to monitor dynamics of extracellular glycine, Published online: 17 August 2018; doi:10.1038/s41589-018-0123-3

A computational design approach was used to develop a genetically encoded FRET-based optical sensor that is aimed at monitoring extracellular glycine levels in brain tissue with the sensitivity and resolution to discern differences in dendritic spine and shaft environment and concentration dynamics upon afferent stimulation.