Flavin doesn’t put all oxygens in one basket

April 22nd, 2020 by David Leys

Nature Chemical Biology, Published online: 22 April 2020; doi:10.1038/s41589-020-0523-z

Oxygen activation mechanisms catalyzed by flavin cofactors are established for electron transfer (oxidases) and C4a covalent flavin–oxygen adduct formation (oxygen-inserting monooxygenases). A new paradigm for oxygen insertion involving a flavin-N5-aminoperoxide intermediate has now been discovered in select flavin-dependent monooxygenases.