Activation of the α<sub>2B</sub> adrenoceptor by the sedative sympatholytic dexmedetomidine

March 9th, 2020 by Daopeng Yuan

Nature Chemical Biology, Published online: 09 March 2020; doi:10.1038/s41589-020-0492-2

A cryo-EM structure of the GPCR α2B adrenergic receptor (α2BAR) in complex with the selective agonist dexmedetomidine and the G protein Go suggests a mechanism of selective activation and provides insights into G-protein coupling activity.
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