Structural basis for selectivity in a highly reducing type II polyketide synthase

May 4th, 2020 by Danyao Du

Nature Chemical Biology, Published online: 04 May 2020; doi:10.1038/s41589-020-0530-0

Structures of the ketosynthase–chain length factor complex from ishigamide biosynthesis, cross-linked to the acyl carrier protein, reveal the molecular interactions between these domains and how the reaction pocket limits rounds of product extension.
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