Protein homeostasis: Modeling UPR adaptive responses

October 17th, 2014 by Danilo B Medinas

Nature Chemical Biology 10, 879 (2014). doi:10.1038/nchembio.1653

Authors: Danilo B Medinas & Claudio Hetz

Understanding the mechanisms that determine cell fate under endoplasmic reticulum (ER) stress had been hampered by the lack of models to study unfolded protein response (UPR) adaptive phases. The development of an engineered protein to conditionally induce its misfolding allowed the establishment of a resolvable ER stress condition.