Protein aggregation: Close encounters of the greasy kind

February 17th, 2015 by Daniel Otzen

Nature Chemical Biology 11, 176 (2015). doi:10.1038/nchembio.1759

Author: Daniel Otzen

Aggregation of α-synuclein (αSN) is critical to the development of Parkinson's disease (PD), but the role of membranes in this process has been unclear and controversial. Galvagnion et al. demonstrate and model how lipids can stimulate αSN aggregation over a narrow range of lipid:protein stoichiometries.