Pluripotency: Citrullination unravels stem cells

April 17th, 2014 by Daniel J Slade

Nature Chemical Biology 10, 327 (2014). doi:10.1038/nchembio.1504

Authors: Daniel J Slade, Venkataraman Subramanian & Paul R Thompson

Maintenance of the pluripotent stem cell state is regulated by the post-translational modification of histones. The discovery that citrullination of the linker histone H1 is critical to this process represents a new role for the protein arginine deiminases in development.