Noncanonical CTD kinases regulate RNA polymerase II in a gene-class-specific manner

December 31st, 2018 by Corey M. Nemec

Noncanonical CTD kinases regulate RNA polymerase II in a gene-class-specific manner

Noncanonical CTD kinases regulate RNA polymerase II in a gene-class-specific manner, Published online: 31 December 2018; doi:10.1038/s41589-018-0194-1

Ten new RNA polymerase II kinases were identified, of these Hrr25 was engineered to enable covalent and noncovalent chemical inhibition in vivo, revealing that this kinase regulates polymerase function at noncoding snoRNA genes.
  • Posted in Nat Chem Biol, Publications
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