The Unexpected Evolution of Basic Science Studies about Cyclic Nucleotide Action into a Treatment for Erectile Dysfunction [Enzymology]

December 11th, 2014 by Corbin, J. D.

In these "Reflections" I will describe my perceived role in discoveries made in the cyclic nucleotide field that culminated in the advent of PDE5 inhibitors that treat erectile dysfunction, such as Viagra®, Levitra®, and Cialis®. The discoveries emphasize the critical role of basic science, which often evolves in unpredictable and circuitous paths, in improving human health.