Synthesis of 11-carbon terpenoids in yeast using protein and metabolic engineering

November 14th, 2018 by Codruta Ignea

Synthesis of 11-carbon terpenoids in yeast using protein and metabolic engineering

Synthesis of 11-carbon terpenoids in yeast using protein and metabolic engineering, Published online: 14 November 2018; doi:10.1038/s41589-018-0166-5

Yeast engineered to produce the six-carbon terpene building block 2-methyl-geranyl diphosphate, coupled with terpene synthases engineered to accept this noncanonical substrate, enables the biosynthesis of a collection of new C11 terpenoid scaffolds.
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