Covalent targeting of the vacuolar H<sup>+</sup>-ATPase activates autophagy via mTORC1 inhibition

July 8th, 2019 by Clive Yik-Sham Chung

Nature Chemical Biology, Published online: 08 July 2019; doi:10.1038/s41589-019-0308-4

A covalent ligand that targets C277 of ATP6V1A was identified resulting in enhanced v-ATPase activity, inhibition of mTORC1 signaling, increased lysosomal acidification, activation of autophagy and clearance of toxic protein aggregates.
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