Laboratory evolution of a sortase enzyme that modifies amyloid-β protein

January 11th, 2021 by Christopher J. Podracky

Nature Chemical Biology, Published online: 11 January 2021; doi:10.1038/s41589-020-00706-1

Laboratory evolution of the bacterial transpeptidase sortase A coupled with yeast display selection enables a change of the enzyme’s substrate preference to recognize and covalently label endogenous amyloid-β protein, impeding the protein’s ability to aggregate.
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