Peroxisomal-derived ether phospholipids link nucleotides to respirasome assembly

March 15th, 2021 by Christopher F. Bennett

Nature Chemical Biology, Published online: 15 March 2021; doi:10.1038/s41589-021-00772-z

A chemical screen identifies DHODH inhibitors as robust activators of mitochondrial respirasome assembly. Lipidomics reveal that peroxisomal-derived ether phospholipids accumulate in mitochondria during nucleotide deprivation to drive proliferation.
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