Conducting the CTD orchestra

December 31st, 2018 by Carlos Mario Genes Robles

Conducting the CTD orchestra

Conducting the CTD orchestra, Published online: 31 December 2018; doi:10.1038/s41589-018-0201-6

The carboxyl-terminal domain (CTD) of RNA polymerase II (Pol II) is post-translationally modified during gene expression. A recent study has identified a CTD kinase, Hrr25, that regulates the termination of noncoding RNA genes by recruiting Rtt103, a key termination factor.