Unraveling proteasome engagement

June 15th, 2020 by Cameron G. Roberts

Nature Chemical Biology, Published online: 15 June 2020; doi:10.1038/s41589-020-0573-2

A new study reveals that, in addition to its longstanding role in recruiting proteins to the proteasome, ubiquitination can also induce a structural destabilization that allows the target protein to be efficiently unraveled for degradation.