Pharmacological perturbation of CDK9 using selective CDK9 inhibition or degradation

December 18th, 2017 by Calla M Olson

Pharmacological perturbation of CDK9 using selective CDK9 inhibition or degradation

Pharmacological perturbation of CDK9 using selective CDK9 inhibition or degradation, Published online: 18 December 2017; doi:10.1038/nchembio.2538

A selective small-molecule degrader of CDK9 was generated by conjugating an imide to SNS-032, a promiscuous ATP-site-directed CDK binder. The pharmacological consequences of CDK9 degradation versus inhibition were compared.
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