Protein dynamics: Conformational footprints
October 18th, 2016 by Buyong Ma
Nature Chemical Biology 12, 890 (2016). doi:10.1038/nchembio.2212
Authors: Buyong Ma & Ruth Nussinov
The mechanisms by which proteins evolve new functions can be slow and mysterious. Comprehensive structural analysis of enzyme variants reveal how gradual enrichments of pre-existing populations with the right productive dynamics for new functions can accomplish this aim.