Drug Discovery: Follow your lead

March 18th, 2014 by Brian K Shoichet

Nature Chemical Biology 10, 244 (2014). doi:10.1038/nchembio.1484

Author: Brian K Shoichet

Probe molecules with systemic activity remain rare, and, as was realized in the pre-molecular era, even their off-target activity can illuminate biology. A study reporting a screen of over 600 kinase inhibitors found nine with bromodomain inhibitory activity and has implications for mechanism and compound optimization.