Conformational rearrangement during activation of a metabotropic glutamate receptor

January 4th, 2021 by Brandon Wey-Hung Liauw

Nature Chemical Biology, Published online: 04 January 2021; doi:10.1038/s41589-020-00702-5

Single-molecule FRET of mGluR2 shows that the conformations of the ligand-binding domain and the linked cysteine-rich domain are loosely coupled during ligand-induced activation and defines two pre-active states linking inactive and active states.
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