PROTAC-mediated degradation reveals a non-catalytic function of AURORA-A kinase

September 28th, 2020 by Bikash Adhikari

Nature Chemical Biology, Published online: 28 September 2020; doi:10.1038/s41589-020-00652-y

A bifunctional AURORA-A degrader induces the fast and specific degradation of this kinase in cancer cell lines, which enables targeting of non-catalytic, oncogenic functions of AURORA-A resulting in S-phase arrest and rampant apoptosis.
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