Discovery of small-molecule enzyme activators by activity-based protein profiling

June 8th, 2020 by Bernard P. Kok

Nature Chemical Biology, Published online: 08 June 2020; doi:10.1038/s41589-020-0555-4

Activity-based protein profiling (ABPP) was used to identify and optimize bioactive, selective pharmacological enzyme activators of the serine hydrolase LYPLAL1, which improved the metabolic defects of diet-induced obese mice.
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