Evolution of cyclohexadienyl dehydratase from an ancestral solute-binding protein

April 23rd, 2018 by Ben E. Clifton

Evolution of cyclohexadienyl dehydratase from an ancestral solute-binding protein

Evolution of cyclohexadienyl dehydratase from an ancestral solute-binding protein, Published online: 23 April 2018; doi:10.1038/s41589-018-0043-2

Ancestral protein reconstruction, with structural and biochemical analysis, illustrates the evolution of a solute-binding protein to cyclohexadienyl dehydratase through incorporation of a catalytic residue and gradual reshaping of the binding site.
  • Posted in Nat Chem Biol, Publications
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