New tricks for an old drug

October 8th, 2018 by Barbara S. Nelson

New tricks for an old drug

New tricks for an old drug, Published online: 08 October 2018; doi:10.1038/s41589-018-0137-x

The prodrug dimethyloxalylglycine (DMOG) is a well-known tool compound used to study hypoxia. New findings reveal that DMOG also inhibits glutamine metabolism and can be exploited to selectively kill some cancer cells, highlighting important caveats when using DMOG for hypoxia studies.