Bromodomain inhibition of the coactivators CBP/EP300 facilitate cellular reprogramming

April 8th, 2019 by Ayyub Ebrahimi

Bromodomain inhibition of the coactivators CBP/EP300 facilitate cellular reprogramming

Bromodomain inhibition of the coactivators CBP/EP300 facilitate cellular reprogramming, Published online: 08 April 2019; doi:10.1038/s41589-019-0264-z

A chromatin-focused chemical screen identified CBP/EP300 bromodomain inhibitors as enhancers of reprogramming. These inhibitors decrease histone H3 lysine 27 acetylation, chromatin accessibility and expression of somatic-specific genes.
  • Posted in Nat Chem Biol, Publications
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