Regulation of apoptosis by an intrinsically disordered region of Bcl-xL

March 5th, 2018 by Ariele Viacava Follis

Regulation of apoptosis by an intrinsically disordered region of Bcl-xL

Regulation of apoptosis by an intrinsically disordered region of Bcl-xL, Published online: 05 March 2018; doi:10.1038/s41589-018-0011-x

Post-translational modification of residues in an intrinsically disordered region of Bcl-XL promotes interactions with its folded core and allosterically reduces affinity for proapoptotic BH3-domain-containing proteins, resulting in apoptosis.
  • Posted in Nat Chem Biol, Publications
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