Engineering orthogonal human <i>O-</i>linked glycoprotein biosynthesis in bacteria

July 27th, 2020 by Aravind Natarajan

Nature Chemical Biology, Published online: 27 July 2020; doi:10.1038/s41589-020-0595-9

An orthogonal O-glycan biosynthesis system was engineered in Escherichia coli to support the production of glycoproteins displaying human mucin O-glycans, including Tn antigens, in living bacteria and in cell-free extracts.
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