Facile target validation in an animal model with intracellularly expressed monobodies

July 16th, 2018 by Ankit Gupta

Facile target validation in an animal model with intracellularly expressed monobodies

Facile target validation in an animal model with intracellularly expressed monobodies, Published online: 16 July 2018; doi:10.1038/s41589-018-0099-z

The development of a selective and potent monobody to WDR5, a component of the mixed linear leukemia methyltransferase complex, as genetically encoded inhibitor enables suppression of leukemogenesis and confers survival in a mouse leukemia model.
  • Posted in Nat Chem Biol, Publications
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