Functional elucidation of TfuA in peptide backbone thioamidation

March 11th, 2021 by Andi Liu

Nature Chemical Biology, Published online: 11 March 2021; doi:10.1038/s41589-021-00771-0

TfuA, YcaO and thiol donor protein, ThiS, collaborate in peptide backbone thioamidation of McrA and during the biosynthesis of certain ribosomally synthesized and post-translationally modified peptide (RiPP) natural products.