Addendum: MCC950 closes the active conformation of NLRP3 to an inactive state
January 25th, 2021 by Ana Tapia-Abellán
Nature Chemical Biology, Published online: 25 January 2021; doi:10.1038/s41589-021-00741-6
Addendum: MCC950 closes the active conformation of NLRP3 to an inactive stateMCC950 closes the active conformation of NLRP3 to an inactive state
May 13th, 2019 by Ana Tapia-Abellán
MCC950 closes the active conformation of NLRP3 to an inactive state
Nature Chemical Biology, Published online: 13 May 2019; doi:10.1038/s41589-019-0278-6
MCC950, a small-molecule inhibitor of the NLRP3 inflammasome, inactivates NLRP3, including hyperactive disease-linked mutations, by closing the ‘open’ conformation, thereby preventing conformational changes required for NLRP3 activation.